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Difluoromethylation of Amines with Zn(CF 3 )Br · 2 CH 3 CN, Cd(CF 3 ) 2 · 2 CH 3 CN and the System Bi(CF 3 ) 3 /AlCl 3
Author(s) -
Pasenok S. V.,
Kirij N. V.,
Yagupolskii Yu. L.,
Naumann D.,
Tyrra W.,
Fitzner A.
Publication year - 1999
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/(sici)1521-3749(199905)625:5<834::aid-zaac834>3.0.co;2-p
Subject(s) - chemistry , medicinal chemistry , bromide , organic chemistry
The reactions of Zn(CF 3 )Br · 2 CH 3 CN, Cd(CF 3 ) 2 · 2 CH 3 CN or Bi(CF 3 ) 3 /AlCl 3 with tertiary amines lead to the formation of quaternary ammonium salts of the general formula [R 3 NCF 2 H]X. The reaction of 4‐N,N‐dimethylaminopyridine with Zn(CF 3 )Br · 2 CH 3 CN yields (N‐difluoromethyl)‐4‐N,N‐dimethylaminopyridinium bromide. Bi(CF 3 ) 3 /AlCl 3 reacts with 1,4‐diazabicyclo[2.2.2]octane to form a mixture of mono‐ and bis(difluoromethylammonium) salts.