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Checkpoints controlling mitosis
Author(s) -
Clarke Duncan J.,
GiménezAbián Juan F.
Publication year - 2000
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/(sici)1521-1878(200004)22:4<351::aid-bies5>3.0.co;2-w
Subject(s) - g2 m dna damage checkpoint , spindle checkpoint , cell cycle checkpoint , chek1 , microbiology and biotechnology , biology , mitosis , kinetochore , computational biology , genetics , cell cycle , chromosome , gene
Abstract Each year many reviews deal with checkpoint con‐trol. (1–5) Here we discuss checkpoint pathways that control mitosis. We address four checkpoint systems in depth: budding yeast DNA damage, the DNA replication checkpoint, the spindle assembly checkpoint and the mammalian G2 topoisomerase II‐dependent checkpoint. A main focus of the review is the organization of these checkpoint pathways. Recent work has elucidated the order‐of‐function of several checkpoint components, and has revealed that the S phase, DNA damage and spindle assembly checkpoints each have at least two parallel branches. These steps forward have largely come from kinetic studies of checkpoint‐defective mutants. BioEssays 22:351–363, 2000. © 2000 John Wiley & Sons, Inc.