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Mammalian chromodomain proteins: their role in genome organisation and expression
Author(s) -
Jones David O.,
Cowell Ian G.,
Singh Prim B.
Publication year - 2000
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/(sici)1521-1878(200002)22:2<124::aid-bies4>3.0.co;2-e
Subject(s) - chromodomain , biology , chromatin , genome , polycomb group proteins , gene , genetics , heterochromatin protein 1 , evolutionary biology , computational biology , gene expression , heterochromatin , helicase , rna , repressor
The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124–137, 2000. ©2000 John Wiley & Sons, Inc.