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Accessing DNA damage in chromatin: Insights from transcription
Author(s) -
Meijer Maria,
Smerdon Michael J.
Publication year - 1999
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/(sici)1521-1878(199907)21:7<596::aid-bies8>3.0.co;2-5
Subject(s) - chromatin , chromatin remodeling , histone modifying enzymes , microbiology and biotechnology , histone code , scaffold/matrix attachment region , transcription coregulator , histone , biology , chip sequencing , chia pet , dna , genetics , computational biology , nucleosome
Recently, there has been a convergence of fields studying the processing of DNA, such as transcription, replication, and repair. This convergence has been centered around the packaging of DNA in chromatin. Chromatin structure affects all aspects of DNA processing because it modulates access of proteins to DNA. Therefore, a central theme has become the mechanism(s) for accessing DNA in chromatin. It seems likely that mechanisms involved in one of these processes may also be used in others. For example, the discovery of transcriptional coactivators with histone acetyltransferase activity and chromatin remodeling complexes has provided possible mechanisms required for efficient repair of DNA in chromatin. BioEssays 21:596–603, 1999. © 1999 John Wiley & Sons, Inc.