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Balanced regulation of microtubule dynamics during the cell cycle: a contemporary view
Author(s) -
Andersen Søren S.L.
Publication year - 1999
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/(sici)1521-1878(199901)21:1<53::aid-bies7>3.0.co;2-l
Subject(s) - microtubule , stathmin , microbiology and biotechnology , microtubule nucleation , microtubule organizing center , spindle pole body , biology , chromosome segregation , mitosis , spindle apparatus , dynamics (music) , microtubule polymerization , multipolar spindles , tubulin , cell division , cell cycle , cell , centrosome , genetics , chromosome , physics , gene , acoustics
Assembly of mitotic and meiotic spindles into an elliptical bipolar shape is an example of morphogenetic processes that involve local chromosomal regulation of microtubule dynamics for proper spatial microtubule assembly. Global microtubule dynamics during the cell cycle and local microtubule dynamics during spindle assembly are regulated by a balance between microtubule stabilizing and destabilizing factors. How a chromosome‐induced phosphorylation gradient may be generated and modulate spindle microtubule assembly through balanced regulation of the activity of microtubule‐associated proteins and Stathmin/Op18 is analyzed. BioEssays 1999;21:53–60. © 1999 John Wiley & Sons, Inc.