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A reassessment of the telomere hypothesis of senescence
Author(s) -
Reddel Roger R.
Publication year - 1998
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/(sici)1521-1878(199812)20:12<977::aid-bies3>3.0.co;2-e
Subject(s) - telomere , senescence , biology , cellular senescence , cellular aging , genetics , telomerase , evolutionary biology , computational biology , dna , gene , phenotype
According to the telomere hypothesis of senescence, the telomeric shortening that accompanies the replication of normal somatic cells acts as the mitotic clock that eventually results in their permanent exit from the cell cycle. Although evidence consistent with the telomere hypothesis continues to accumulate, on the basis of recent findings it is suggested that instead of a single clock mechanism there are multiple inducers of senescence. BioEssays 20:977–984, 1998. © 1998 John Wiley & Sons, Inc.