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Author(s) -
Morrison A.D.
Publication year - 1998
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/(sici)1521-1878(199810)20:10<794::aid-bies4>3.0.co;2-e
Subject(s) - biology
Expression and mutational analysis has shown that the vertebrate Hox genes are instrumental in patterning of the developing embryo. However, the combined effects of functional redundancy, compensation, and synergy often obscure the precise roles of these genes. (1) By combining gene targeting strategies with the analysis of regulatory sequences from the Hoxa1 and Hoxb1 genes, (2,3) it has been possible to bypass some of these complications and demonstrate their genetic and functional interactions during the development of the hindbrain and branchial arches. BioEssays 20 :794–797, 1998. © 1998 John Wiley & Sons, Inc.