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Effect of 50 Hz sinusoidal electromagnetic field on the kinetics of 14 CO 2 exhalation after [ 14 C]‐N‐Nitrosodiethylamine administration in mice
Author(s) -
Singh Satnam,
Khanduja K.L.,
Mittal P.K.
Publication year - 1999
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/(sici)1521-186x(1999)20:1<1::aid-bem1>3.0.co;2-5
Subject(s) - exhalation , carcinogen , chemistry , electromagnetic field , metabolism , pharmacology , body weight , medicine , biochemistry , anesthesia , physics , quantum mechanics
N‐Nitrosodiethylamine (NDEA) has been identified as a typical environmental carcinogen. Its metabolism was studied in mice under the influence of an electromagnetic field (EMF). After intraperitoneal administration of [ 14 C]‐NDEA, 0.2 μCi/100 g body weight resulted in 22.8% of the total radioactivity exhaled as 14 CO 2 within 1 h. Mice were exposed to a 50 Hz, 2 mT (rms) electromagnetic field, 8 h/day for 8 weeks. There was a significant increase in the metabolic turnover of [ 14 C]‐NDEA into 14 CO 2 at the end of both 6 and 8 weeks of field exposure, i.e., 26.9% and 37.4% respectively. The enhanced capacity of mice to metabolize NDEA after the exposure to EMF may result in animals with a smaller amount of the bioactive carcinogen burden, thereby indicating a protective role of 2 mT EMF in a whole animal study. Bioelectromagnetics 20:1–4, 1999. © 1999 Wiley‐Liss, Inc.