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Nonbinomial distributions of relative neurite outgrowth in PC‐12 cells
Author(s) -
Blackman Carl F.,
House Dennis E.,
Blanchard Janie Page
Publication year - 1996
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/(sici)1521-186x(1996)17:6<512::aid-bem13>3.0.co;2-m
Subject(s) - neurite , biophysics , chemistry , biology , in vitro , biochemistry
Previously we reported the results of a series of experimental tests using PC‐12 cells to examine the biological effects of prescribed combinations of both nerve growth factor and magnetic fields. Because our assay of the PC‐12 cells is based on a binary classification of the cells following treatment, our data might be expected to have a binomial distribution. However, our data consistently show a smaller variability than that predicted by the binomial distribution model. In this paper, we examine some possible reasons for this reduction in variability in our results. © 1996 Wiley‐Liss, Inc.