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Dynamic urinary graciloplasty in male goats: A study on histology and urethral pressures
Author(s) -
Heesakkers John,
Jianguo Wen,
de Bruïne Adriaan,
van den Bogaard Anton,
Janknegt Rudi
Publication year - 1998
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/(sici)1520-6777(1997)16:2<117::aid-nau5>3.0.co;2-h
Subject(s) - medicine , stimulation , urethra , histology , urology , anatomy , connective tissue , urinary system , surgery , pathology
Abstract The purpose of this study was to investigate the feasibility of dynamic bulbous urinary graciloplasty with respect to graciloplasty histology and urethral pressures. Two adult male goats underwent a pulled‐through bulbous urethral graciloplasty with implant of electrodes and a pulse stimulator. Afterwards, a stimulation protocol was applied to have the fatiguable type II fibers replaced by fatigue‐resistant type I fibers. Urethral pressure profilometry as well as analysis of histology was performed afterwards and compared with preoperative biopsies and preoperative recorded urethral pressures. Successful conversion from type II into type I muscle fibers was observed; the percentage of type I fibers increased from 29% to 83%. The percentage of connective tissue increased from 8% to 16%. No stricturing of the bulbous urethra was observed. The urethral pressures before stimulation increased from a mean of 107 cm H 2 O without stimulation, to 187 cm H 2 O with stimulation for the two goats. After training, the urethral pressure increased from a mean of 85 cm H 2 O without stimulation, to 118 cm H 2 O with stimulation. In male goats, successful dynamic urinary graciloplasty at the bulbous urethra is feasible. The achieved muscle fiber conversion guarantees fatigue‐resistance, necessary for a continuous sphincteric muscle contraction. The maximal urethral pressures, however, are lower than those without stimulation. Neurourol. Urodynam. 16:117–123, 1997. © 1997 Wiley‐Liss, Inc.