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Cell‐surface expression of L‐selectin (CD62L) by blood lymphocytes: Correlates with affective parameters and severity of panic disorder
Author(s) -
Manfro Gisele G.,
Pollack Mark H.,
Otto Michael W.,
Worthington John J.,
Rosenbaum Jerrold F.,
Scott Erin L.,
Kradin Richard L.
Publication year - 2000
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/(sici)1520-6394(2000)11:1<31::aid-da5>3.0.co;2-o
Subject(s) - panic disorder , panic , l selectin , immunology , anxiety , immune system , lymphocyte , psychology , medicine , lymphocyte homing receptor , receptor , psychiatry , cell , biology , cell adhesion , genetics
The surface immune phenotype of peripheral blood lymphocytes (PBL) was examined in 30 patients meeting DSM‐III‐R criteria for panic disorder and in 10 normal controls by immunostaining and cytofluorimetry. Patients with panic disorder and controls showed comparable numbers of PBL and no differences in the percentages of blood T‐cells, B‐cells, or NK‐cells. The PBL in panic disorder patients showed a trend toward enrichment for “naive” CD45RA+ T‐lymphocytes (35.0 ± 7.6 vs. 28.7 ± 9.8, P = 0.09) and significant enrichment for cells expressing CD62L (L‐selectin, 22.9 ± 5.9 vs. 14.6 ± 6.3, P = 0.002), a lymphocyte homing receptor that mediates binding to lymph node endothelium. Increased expression of CD62L correlated directly with the global severity of illness, Hamilton Anxiety (HAM‐A) and Hamilton Depression (HAM‐D) scores. Although in the normal range, plasma cortisol levels were significantly increased in patients with panic disorder ( P = 0.003) with respect to controls and correlated with the expression of CD62L by PBL. We conclude that the peripheral blood in panic disorder shows phenotypic changes that may reflect diminished cell activation in vivo. Depression and Anxiety 11:31–37, 2000.© 2000 Wiley‐Liss, Inc.