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Six‐month outcomes for MRI‐related vascular depression
Author(s) -
Krishnan K. Ranga Rama,
Hays Judith C.,
George Linda K.,
Blazer Dan G.
Publication year - 1998
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/(sici)1520-6394(1998)8:4<142::aid-da2>3.0.co;2-n
Subject(s) - depression (economics) , medicine , psychology , psychiatry , cardiology , economics , macroeconomics
The purpose of this paper is to estimate the relative probabilities of 6‐month recovery from an index episode of major depression for subjects with and without MRI‐confirmed vascular brain changes. In this cohort study, 57 depressed subjects from the Duke University Mental Health Clinical Research Center (MHCRC) for Depression in Late Life who presented with MRI‐related vascular and non‐vascular depression were followed for 6 months, and the rates of recovery in the two risk groups were compared. Overall, the recovery rate in this sample was 57.9%. Subjects with MRI‐related vascular depression demonstrated outcomes similar to subjects with non‐vascular depression (crude RR=0.67[0.32,1.43]). There was a trend that demonstrated that MRI‐related vascular depression placed elderly subjects and subjects with first onset of depression after age 40 at increased risk of non‐recovery. The study demonstrates overall no significant difference in course between patients with and without vascular depression. It also suggests that patients with vascular depression may have a different course depending on their age and age of onset of the disease. Depression and Anxiety 8:142–146, 1998.© 1998 Wiley‐Liss, Inc.