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Psychostimulant augmentation of second generation antidepressants: A case series
Author(s) -
Masand Prakash S.,
Anand Vishal S.,
Tanquary John F.
Publication year - 1998
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/(sici)1520-6394(1998)7:2<89::aid-da8>3.0.co;2-0
Subject(s) - apathy , antidepressant , major depressive disorder , depression (economics) , psychiatry , psychology , feeling , medicine , anxiety , mood , cognition , economics , macroeconomics , social psychology
Objective The authors attempted to treat Major Depressive Disorder (MDD) suboptimally responsive to one of the newer (second‐generation) antidepressants by augmentation with a psychostimulant medication. Method: Seven cases of MDD showing a partial response to an adequate trial of a second generation antidepressant were augmented with a psychostimulant. Results: A marked improvement in clinical symptoms of depression was noted in all cases, with particular improvement in apathy and feelings of fatigue. Conclusion: Psychostimulant augmentation of the newer generation antidepressants is a promising new strategy. Further controlled investigation is warranted to explore various aspects of this method. Depression and Anxiety 7:89–91, 1998. © 1998 Wiley‐Liss, Inc.