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Use of bupropion with SRIs and venlafaxine
Author(s) -
Spier Scott A.
Publication year - 1998
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/(sici)1520-6394(1998)7:2<73::aid-da4>3.0.co;2-6
Subject(s) - bupropion , venlafaxine , medicine , combination therapy , antidepressant , smoking cessation , pathology , hippocampus
Because of reported efficacy of combining classes of antidepressants, 25 patients were treated with bupropion in combination with SRI's and venlafaxine. Fifteen patients inadequately responsive to monotherapy received combination treatment; ten patients without residual symptoms received adjunctive bupropion to treat SRI‐ or venlafaxine‐induced side effects. Fourteen subjects (56%) responded, 11 (44%) did not. Twelve of 15 subjects receiving combination treatment to boost the effects of monotherapy responded, while only 2 of 10 subjects receiving combination treatment for side effects responded. Combination therapy was well tolerated even by geriatric and “medically frail” patients. Depression and Anxiety 7:73–75, 1998. © 1998 Wiley‐Liss, Inc.