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Optically active titanium complexes containing a tridentate linked amido‐cyclopentadienyl ligand
Author(s) -
Okuda Jun,
Verch Sabine,
Stürmer Rainer,
Spaniol Thomas P.
Publication year - 2000
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(2000)12:5/6<472::aid-chir30>3.0.co;2-q
Subject(s) - chemistry , cyclopentadienyl complex , chirality (physics) , acetophenone , ligand (biochemistry) , titanium , optically active , stereochemistry , crystal structure , planar chirality , crystallography , butyllithium , group (periodic table) , medicinal chemistry , enantioselective synthesis , catalysis , organic chemistry , receptor , biochemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Optically active titanium complexes Ti{η 5 :η 1 ‐C 5 R 4 SiMe 2 NC 6 H 10 (OCH 2 Ph)‐2}Cl 2 (R = H, Me), containing a cyclopentadienyl ligand linked to the chiral trans‐2‐benzyloxycyclohexylamido group, were synthesized and characterized in both enantiomerically pure forms. A single crystal X‐ray structure analysis of (−)‐(R,R)‐Ti{η 5 :η 1 ‐C 5 H 4 SiMe 2 NC 6 H 10 (OCH 2 Ph)‐2}Cl 2 shows a structure in which the benzyloxy group in the amido sidechain is not interacting with the titanium center. Upon activation with n‐butyllithium, these complexes hydrogenate acetophenone N‐benzylimine with low enantioselectivity. Chirality 12:472–475, 2000. © 2000 Wiley‐Liss, Inc.