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Short step enantioselective synthesis of (−)‐swainsonine
Author(s) -
Punniyamurthy T.,
Irie Ryo,
Katsuki Tsutomu
Publication year - 2000
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(2000)12:5/6<464::aid-chir28>3.0.co;2-z
Subject(s) - chemistry , desymmetrization , enantioselective synthesis , swainsonine , optically active , combinatorial chemistry , catalysis , stereochemistry , organic chemistry
Recent discovery of asymmetric desymmetrization of meso ‐heterocycles using ( R,R )‐(salen)manganese complex 2 as a catalyst allowed easy access to optically active 2,3,4‐trisubstituted pyrrolidines. Taking advantage of this new reaction, we could achieve the short‐step synthesis of (−)‐swainsonine 1 . Chirality 12:464–468, 2000. © 2000 Wiley‐Liss, Inc.