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Preparation of new chiral borane‐protected P,N‐ferrocenyl ligands via a methoxy directed ortho‐ lithiation
Author(s) -
Lotz Matthias,
Ireland Tania,
Tappe Katja,
Knochel Paul
Publication year - 2000
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(2000)12:5/6<389::aid-chir16>3.0.co;2-s
Subject(s) - chemistry , borane , diastereomer , enantiomer , chelation , catalysis , metal , ferrocene , stereochemistry , medicinal chemistry , organic chemistry , electrode , electrochemistry
We have shown that the readily prepared (ferrocenyl)benzylic methyl ethers of type 1 can be ortho‐ metalated with tert‐ BuLi with high diastereoselectivity. This reaction has been used to prepare new borane‐protected P,N‐substituted ferrocenes of type 2 in high diastereomeric and enantiomeric purity. The chiral heterocyclic aminophosphines 2 may be of interest as chelating ligands for asymmetric metal catalysis. Chirality 12:389–395, 2000. © 2000 Wiley‐Liss, Inc.