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Design, optimization, and operation of SMB chromatography in the production of enantiomerically pure pharmaceuticals
Author(s) -
Strube Jochen,
Jupke Andreas,
Epping Achim,
SchmidtTraub Henner,
Schulte Michael,
Devant Ralf
Publication year - 1999
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1999)11:5/6<440::aid-chir15>3.0.co;2-k
Subject(s) - chemistry , simulated moving bed , derivative (finance) , countercurrent exchange , process (computing) , chromatography , chiral stationary phase , process engineering , high performance liquid chromatography , organic chemistry , computer science , thermodynamics , physics , financial economics , operating system , adsorption , engineering , economics
The utility of simulated moving bed (SMB) chromatography for the preparative chromatographic enantioseparation on chiral stationary phases (CSP) is shown. A design and optimization methodology is proposed and verified with production scale enantioseparations. The study combines two modelling approaches. The equilibrium theory for true countercurrent (TCC) liquid chromatography is used to generate a first set of operating parameters. Afterwards, detailed process optimization is done by systematic simulation studies with the rigorous dynamic SMB process model. Using the preparative enantioseparations of two new drug candidates, EMD 53986 a precursor of a cardiovascular drug and a chroman ester derivative which is a precursor of EMD 128130, the model approaches are verified and compared. The necessity and benefit of careful system design and optimization by detailed process simulation is demonstrated. Chirality 11:440–450, 1999. © 1999 Wiley‐Liss, Inc.