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A quantitation of stereoselectivity by the Free‐Wilson method
Author(s) -
HernandezGallegos Zurisaddai,
Lehmann F. Pedro A.
Publication year - 1999
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1999)11:2<139::aid-chir10>3.0.co;2-7
Subject(s) - stereoselectivity , chemistry , muscarinic acetylcholine receptor , chirality (physics) , stereochemistry , receptor , biochemistry , catalysis , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
The stereoselectivity of muscarinic receptors was quantified by the Free‐Wilson method. The analysis was performed with the affinity data, published by Gualtieri for certain muscarinic ligands (1,3‐oxathiolanes) in three different tissues. The 2 and 3 positions in the 1,3‐oxathiolane ring were important to differentiate between the receptors in those tissues. The results also showed that the three chiral centers in the 1,3‐oxathiolanes displayed different stereoselective discrimination. The results of the Free‐Wilson analysis were compared with those of a previous study on the same compounds obtained by epimeric eudismic analysis. The agreements and differences between the results obtained by these two methods are discussed in depth. Chirality 11:139–143, 1999. © 1999 Wiley‐Liss, Inc.