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Direct separation of α‐hydroxy acid enantiomers by ligand exchange chromatography
Author(s) -
Chilmonczyk Zdzisław,
Ksycińska Hanna,
Cybulski Jacek,
Rydzewski Mariusz,
Leś Andrzej
Publication year - 1998
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1998)10:9<821::aid-chir8>3.0.co;2-c
Subject(s) - chemistry , enantiomer , chirality (physics) , ligand (biochemistry) , elution , ternary operation , aqueous solution , chromatography , chiral column chromatography , phase (matter) , silica gel , computational chemistry , organic chemistry , biochemistry , receptor , computer science , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , programming language , quark
Direct separation of several α‐hydroxy acid racemic mixtures was performed by the aid of ligand exchange chromatography using L‐hydroxyproline chemically bound to silica stationary phase and aqueous solutions of copper (II) sulphate as a mobile phase. The elution order of the D‐ and L‐enantiomers of α‐hydroxy acids is interpreted in terms of a modified Davankov's rule. Several aspects of the Davankov's model of selectand‐Cu(II)‐selector ternary complexes are discussed based on the theoretical calculations within the quantum mechanical semiempirical and density functional theories. Chirality 10:821–830, 1998. © 1998 Wiley‐Liss, Inc.