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Preparative enantioseparation on polysaccharide phase using microporous silica as a support
Author(s) -
Tiritan Maria E.,
Cass Quezia B.,
Del Alamo Aurora,
Matlin Stephen A.,
Grieb Sally J.
Publication year - 1998
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1998)10:7<573::aid-chir4>3.0.co;2-3
Subject(s) - chemistry , microporous material , polysaccharide , phase (matter) , chromatography , organic chemistry
The preparative enantiomeric resolutions of hexahelicen‐7‐yl acetic acid methyl ester and two sulphoxides were performed on cellulose tris(3,5‐dimethylphenylcarbamate) coated onto aminopropylated 5‐μm silica with 120‐Å diameter pore. High enantiomeric purity was obtained for both enantiomers. The enantioselectivity of the amylose tris(3,5‐dimethylphenylcarbamate), cellulose and amylose tris(phenylcarbamate) phases for the hexahelicen‐7‐yl acetic acid derivative were also investigated. Chirality 10:573–577, 1998. © 1998 Wiley‐Liss, Inc.