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Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma‐cyclodextrin as chiral solvating agent
Author(s) -
Koppenhoefer Bernhard,
Epperlein Ulrich,
Jakob Andreas,
Wuerthner Stefan,
Xiaofeng Zhu,
Bingcheng Lin
Publication year - 1998
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1998)10:6<548::aid-chir8>3.0.co;2-#
Subject(s) - chemistry , capillary electrophoresis , enantiomer , cyclodextrin , chromatography , chiral derivatizing agent , combinatorial chemistry , chiral column chromatography , organic chemistry
Following an extended chiral drug screening program by capillary zone electrophoresis (CZE), the enantioseparation of 86 racemic drugs was tested with γ‐cyclodextrin as a chiral solvating agent. Unified conditions were applied to all experiments. In total, 18 drug racemates were separated, 13 entries thereof that had not been separated at the lower CSA concentration applied in an earlier stage of the project. A comparison of the data with the results obtained for α‐ and β‐cyclodextrin points to the significance of partial penetration (“side‐on binding”) of aryl groups into the cyclodextrin cavity. Chirality 10:548–554, 1998. © 1998 Wiley‐Liss, Inc.