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Immobilized vancomycin as chiral stationary phase in packed capillary liquid chromatography
Author(s) -
Svensson Lars A.,
Karlsson KarlErik,
Karlsson Anders,
Vessman Jörgen
Publication year - 1998
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1998)10:3<273::aid-chir10>3.0.co;2-x
Subject(s) - chemistry , enantiomer , chromatography , chirality (physics) , enantioselective synthesis , reductive amination , capillary action , phase (matter) , aldehyde , packed bed , capillary electrochromatography , chiral column chromatography , organic chemistry , stationary phase , catalysis , physics , chiral symmetry breaking , materials science , quantum mechanics , nambu–jona lasinio model , composite material , quark
Fused silica‐packed capillary columns containing vancomycin immobilized by reductive amination on an aldehyde‐silica were used to separate enantiomers of some non‐steroidal anti‐inflammatory drugs. Attempts have been made to qualitatively explain the influence of various mobile phase compositions on the enantioselective retention. The effects of mobile phase pH, buffer, and organic modifier concentrations were investigated as well as the influence of salts of hydrophobic ions added to the mobile phase to induce ion pair retention. Chirality 10: 273–280, 1998. © 1998 Wiley‐Liss, Inc.