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Temperature effects for chiral separations using various bulk fluids in near‐critical mobile phases
Author(s) -
Blackwell John A.,
Stringham Rodger W.
Publication year - 1997
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1997)9:7<693::aid-chir10>3.0.co;2-i
Subject(s) - chemistry , supercritical fluid chromatography , chirality (physics) , selectivity , supercritical fluid , phase (matter) , supercritical carbon dioxide , polar , carbon dioxide , chromatography , chemical engineering , chiral column chromatography , organic chemistry , high performance liquid chromatography , catalysis , chiral symmetry breaking , physics , engineering , quantum mechanics , astronomy , nambu–jona lasinio model , quark
As supercritical fluid chromatography becomes more accepted as a facile means for the separation of chiral compounds, the need for mobile phases that can readily solubilize these polar compounds grows. Prior studies suggest that HFC‐134a may prove suitable due to its very high eluotropic strength compared to carbon dioxide‐based mobile phases. A comparison is made between ethanol‐modified carbon dioxide, HFC‐134a, and decafluoropentane as to their relative eluotropic strength, selectivity, and efficiency for three chiral compounds using a Whelk O‐1 chiral bonded phase. The bulk component of the mobile phase was found to have relatively little effect on chiral selectivity over the range of 5° to 95°C. Chirality 9:693–698, 1997. © 1997 Wiley‐Liss, Inc.