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Improvement of enantioselective syntheses and chiral high resolution gas chromatographic analyses of (+)‐2‐allyl‐2‐carboethoxy‐cyclopentanol
Author(s) -
Fraga Carlos A. M.,
Barreiro Eliezer J.,
da Silva Edson F.,
dos Santos Anderson R.,
Ramos Maria da Conceição K. V.,
de Aquino Neto Francisco R.
Publication year - 1997
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1997)9:4<321::aid-chir1>3.0.co;2-g
Subject(s) - chemistry , chirality (physics) , enantioselective synthesis , cyclopentanone , derivative (finance) , yield (engineering) , resolution (logic) , gas chromatography , chiral resolution , cyclodextrin , chromatography , organic chemistry , enantiomer , catalysis , physics , artificial intelligence , computer science , financial economics , economics , chiral symmetry breaking , materials science , quantum mechanics , nambu–jona lasinio model , metallurgy , quark
The improvement of the biocatalytic reduction of 2‐allyl‐carboethoxy‐cyclopentanone ( 2 ) to the corresponding cyclopentanol derivative (+)‐ (1R,2R)‐(1) was accomplished employing baker's yeast in organic media. This chiral cyclopentanol derivative ( 1 ), analyzed by high resolution gas chromatography performed over β‐cyclodextrin stationary phase, was obtained in 38% yield (>99% e.e. ). Chirality 9:321–324, 1997. © 1997 Wiley‐Liss, Inc.