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Capillary electrophoretic chiral resolution of vicinal diols by complexation with borate and cyclodextrin: Comparative studies on different cyclodextrin derivatives
Author(s) -
Schmid Martin G.,
Wirnsberger Karin,
Jira Thomas,
Bunke Antje,
Gübitz Gerald
Publication year - 1997
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1997)9:2<153::aid-chir14>3.0.co;2-m
Subject(s) - chemistry , cyclodextrin , vicinal , capillary electrophoresis , chirality (physics) , boron , enantioselective synthesis , diol , chiral resolution , resolution (logic) , inclusion compound , analyte , enantiomer , combinatorial chemistry , organic chemistry , stereochemistry , chromatography , catalysis , chiral symmetry breaking , physics , quantum mechanics , artificial intelligence , computer science , nambu–jona lasinio model , quark
Capillary electrophoretic enantioseparation of compounds containing vicinal diol groups have been investigated using different β‐cyclodextrin (CD) derivatives and borate as a background electrolyte. Both native β‐CD and several β‐CD derivatives are examined. Chiral recognition is attributed to both enantioselective inclusion of the analyte into the chiral cavity of the CD and complexation with borate. The influence of concentration of the chiral selector, pH, and organic modifiers on the resolution was studied. Four diols were baseline separated. Chirality 9:153–156, 1997. © 1997 Wiley‐Liss, Inc.