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Comparison of capillary electrophoresis and liquid chromatography for the enantiomeric separation of α‐phosphonosulfonic acids
Author(s) -
Bretnall A. F.,
Hodgkinson M. M.,
Clarke G. S.
Publication year - 1997
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1997)9:2<104::aid-chir5>3.0.co;2-h
Subject(s) - chemistry , capillary electrophoresis , enantiomer , chromatography , cyclodextrin , chirality (physics) , chiral column chromatography , electrophoresis , high performance liquid chromatography , chiral derivatizing agent , electrolyte , organic chemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark , electrode
The enantiomers of α‐phosphonosulfonic acids were completely resolved by capillary electrophoresis using β‐cyclodextrin as a chiral selector in a borate electrolyte and HPLC using a chiral AGP column. The methods were used to quantitate the R‐enantiomer present as an impurity in the S‐enantiomer, a potential cardiovascular drug candiate. Chirality 9:104–108, 1997. © 1997 Wiley‐Liss, Inc.