Premium
Chiral synthesis and pharmacological evaluation of the enantiomers of SM 32 , a new analgesic and cognition‐enhancing agent
Author(s) -
Romanelli Maria Novella,
Bartolini Alessandro,
Bertucci Carlo,
Dei Silvia,
Ghelardini Carla,
Giovannini Maria Grazia,
Gualtieri Fulvio,
Pepeu Giancarlo,
Scapecchi Serena,
Teodori Elisabetta
Publication year - 1996
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1996)8:8<579::aid-chir7>3.0.co;2-4
Subject(s) - chemistry , enantiomer , analgesic , cognition , chirality (physics) , enantioselective synthesis , pharmacology , combinatorial chemistry , stereochemistry , psychology , neuroscience , organic chemistry , catalysis , medicine , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
The enantiomers of 3‐α‐tropyl 2‐(phenylthio)butyrate (SM 32 , 1 ) were prepared by chiral synthesis and tested for analgesic, cognition‐enhancing, and ACh‐releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R‐(+)‐hyoscyamine. Chirality 8:579–584, 1996. © 1997 Wiley‐Liss, Inc.