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NMR investigation of the interaction of (+)‐ and (−)‐flurbiprofen with β‐cyclodextrin
Author(s) -
Salvadori Piero,
UccelloBarretta Gloria,
Balzano Federica,
Bertucci Carlo,
Chiavacci Claudia
Publication year - 1996
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1996)8:6<423::aid-chir3>3.0.co;2-d
Subject(s) - chemistry , flurbiprofen , cyclodextrin , relaxation (psychology) , proton nmr , stereochemistry , proton , sodium , organic chemistry , pharmacology , medicine , psychology , social psychology , physics , quantum mechanics
The sodium salts of (+)‐(S)‐ and (−)‐(R)‐2‐(2‐fluoro‐4‐biphenylyl)propionic acid (flurbiprofen, FBP) form 1:1 inclusion complexes with β‐cyclodextrin (β‐CD) having different association constants. Proton selective relaxation rate measurements revealed the existence of superior aggregated forms for both complexes (+)‐FBP/β‐CD and (−)‐FBP/β‐CD; information about their stereochemistry has been obtained by 2D ROESY analysis. © 1996 Wiley‐Liss, Inc.