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Design and development of chiral reagents for the chromatographic e.e. determination of chiral alcohols
Author(s) -
Walther Willi,
Netscher Thomas
Publication year - 1996
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1996)8:5<397::aid-chir7>3.0.co;2-b
Subject(s) - chemistry , chiral derivatizing agent , reagent , chromatography , chirality (physics) , chiral stationary phase , combinatorial chemistry , enantiomer , organic chemistry , chiral column chromatography , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
( S )‐Trolox methyl ether is known as a powerful chiral reagent for the e.e. determination of chiral alcohols by separation of the corresponding diastereoisomeric esters on achiral GC and SFC columns. In order to further improve his methodology, five possible candidates resultings from variation of structural elements of parent reagent have been tested for derivatization with selected alcohols and subsequent analysis of the diastereoisomeric pairs of esters. The results of this optimization procedure showing the ways to new potent reagents are discussed. © 1996 Wiley‐Liss, Inc.