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Enantiomeric enrichment of non‐racemic mixtures of binaphthol with non‐chiral packings
Author(s) -
Nicoud RogerMarc,
Jaubert JeanNoël,
Rupprecht Isabell,
Kinkel Joachim
Publication year - 1996
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1996)8:3<234::aid-chir2>3.0.co;2-h
Subject(s) - enantiomer , chemistry , enantiomeric excess , elution , racemic mixture , chromatography , fraction (chemistry) , organic chemistry , enantioselective synthesis , catalysis
It is shown that chromatography with achiral phases of non‐racemic mixture of binaphthol can furnish fractions which differ in enantiomeric excess. The first fraction contains one pure enantiomer i.e., has an enantiomeric excess (ee %) close to 100% and the following fractions have an ee % close to 0% (racemic mixture). As a consequence, such chromatography may be used to enrich a non‐racemic mixture of binaphthol in one enantiomer. In this paper a model is proposed allowing us to calculate with good accuracy the experimental elution curves. This simple model is capable of using only a few chromatographic experiments to predict the enantiomeric enrichment of a non‐racemic mixture and to calculate precisely the retention time of each fraction. © 1996 Wiley‐Liss, Inc.