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Separation of enantiomers using vancomycin in a countercurrent process by suppression of electroosmosis
Author(s) -
Ward Timothy J.,
Dann Charles,
Brown Andy P.
Publication year - 1996
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1996)8:1<77::aid-chir13>3.0.co;2-p
Subject(s) - chemistry , countercurrent exchange , enantiomer , capillary electrophoresis , chromatography , adsorption , resolution (logic) , absorbance , electrophoresis , organic chemistry , physics , artificial intelligence , computer science , thermodynamics
Excellent separations were achieved using a coated column to suppress electroosmotic flow and employing a countercurrent process between chiral selector and racemic solute. Using the macrocyclic antibiotic vancomycin as a chiral selector in capillary electrophoresis the resolution of nonsteroidal antiinflammatories and dansyl amino acids was achieved. Improvement in sensitivity due to the elimination of background absorbance and increased efficiency due to the removal of wall adsorption effects are both achieved using this technique. © 1996 Wiley‐Liss. Inc.