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Ion channels as pharmacologic receptors: The chirality of drug interactions
Author(s) -
Triggle David J.
Publication year - 1996
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/(sici)1520-636x(1996)8:1<35::aid-chir8>3.0.co;2-f
Subject(s) - chemistry , stereoselectivity , ion channel , chirality (physics) , receptor , stereochemistry , ion , drug , biophysics , pharmacology , biochemistry , organic chemistry , medicine , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , biology , quark , catalysis
Ion channels are pharmocologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na + and Ca 2+ channels. © 1996 Wiley‐Liss, Inc.