Premium
20‐hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation
Author(s) -
Trenin Dmitry S.,
Volodin Vladimir V.
Publication year - 1999
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/(sici)1520-6327(1999)41:3<156::aid-arch7>3.0.co;2-q
Subject(s) - 20 hydroxyecdysone , in vitro , biology , intracellular , lymphocyte , respiratory burst , pharmacology , biochemistry , immunology , gene
20‐hydroxyecdysone (1 μM) was found to activate in vitro T‐cell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels. The compound was found to act like a synthetic psycho‐immunomodulator 1‐oxy‐4‐oxoadamantane (1 μM) and to exceed the effects of the thymomimetic agent levamisol (1 μM). In addition, 20‐hydroxyecdysone (1 μM) was also revealed to modulate the fluoride‐stimulated respiratory burst of human neutrophils in the same manner as water soluble antioxidants. Arch. Insect Biochem. Physiol. 41:156–161, 1999. © 1999 Wiley‐Liss, Inc.