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The ecdysone receptor puzzle
Author(s) -
Lezzi M.,
Bergman T.,
Mouillet J.F.,
Henrich V.C.
Publication year - 1999
Publication title -
archives of insect biochemistry and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 66
eISSN - 1520-6327
pISSN - 0739-4462
DOI - 10.1002/(sici)1520-6327(1999)41:2<99::aid-arch6>3.0.co;2-w
Subject(s) - ecdysone receptor , transactivation , ecdysone , biology , nuclear receptor , receptor , microbiology and biotechnology , estrogen related receptor gamma , enzyme linked receptor , transcription factor , hormone , biochemistry , gene
The present article reviews some recent findings on the functional ecdysone receptor which is a heterodimer of two proteins: ecdysone receptor (EcR) and Ultraspiracle (USP). Emphasis is given to some unique aspects of this receptor, in particular to its dimerization, binding to DNA, and transactivation capabilities. The effects of ligands (ecdysone, juvenile hormone) on these functions are discussed. In addition, perspectives on future work on this receptor are outlined, which are shaped by recent progress in the nuclear receptor field in general. This preview part of the present article concerns mainly the 3‐D structure of receptor domains, the formation of large supramolecular receptor complexes, their influence on chromatin remodelling, receptor phosphorylation, as well as inter‐ and intramolecular cross‐talks of receptor domains. Arch. Insect Biochem. Physiol. 41:99–106, 1999. © 1999 Wiley‐Liss, Inc.