Premium
Interethnic genetic differentiation: HLA class I antigens in the population of Mongolia
Author(s) -
Chimge NyamOsorin,
Batsuuri Jamiyangiin
Publication year - 1999
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/(sici)1520-6300(199909/10)11:5<603::aid-ajhb4>3.0.co;2-c
Subject(s) - haplotype , indigenous , population , ethnic group , locus (genetics) , human leukocyte antigen , biology , genetic diversity , evolutionary biology , genetic variation , genetics , antigen , allele , demography , geography , gene , ecology , anthropology , sociology
A total of 1668 individuals representing 10 major Mongolian ethnic groups were serologically typed for HLA‐A, ‐B, and ‐C antigens. Antigens A2, A24, B61, B51, B58, Cw3, Cw7, and Cw6 were the most frequent specificities in Mongolians and no case of B42 was noted in all ethnic groups. The cluster analysis of Principal Components I and II shows that Mongolian speaking groups form one cluster vs Turkic‐speaking Kazakhs. The analysis reveals a low, but significant differentiation of Mongolian ethnic groups as measured by F ST = 0.0100 ( P < 0.001). Gene diversity analysis shows that the genetic diversity of the Mongolian population can be attributed largely to its ethnic component, which makes up 64% of total genetic variation. The low degree of interpopulation variation and high level of intrapopulation diversity can be explained by the nomadic way of life of this indigenous population. Three‐locus haplotypes A24‐B61‐Cw3, A33‐B58‐Cw3 are the most common haplotypic associations in Mongolians. The presence of antigens characteristic of Mongoloid, Caucasoid, and Negroid populations in Mongolians suggests a unique genetic background of this indigenous population. The three‐locus haplotype distribution among Mongolians relative to other world populations supports the migration of ancient people from Central Asia to the New World, Korean Peninsula, and Southeast Asia. Am. J. Hum. Biol. 11:603–618, 1999. © 1999 Wiley‐Liss, Inc.