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Reproducibility of PET brain mapping of cancer patients
Author(s) -
Tashiro Manabu,
Juengling Freimut D.,
Reinhardt Michael J.,
Brink Ingo,
Hoegerle Stefan,
Mix Michael,
Kubota Kazuo,
Yamaguchi Keiichiro,
Itoh Masatoshi,
Sasaki Hidetada,
Moser Ernst,
Nitzsche Egbert U.
Publication year - 2000
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/(sici)1099-1611(200003/04)9:2<157::aid-pon452>3.0.co;2-y
Subject(s) - medicine , brain cancer , basal ganglia , basal (medicine) , cancer , depression (economics) , posterior cingulate , positron emission tomography , cingulate cortex , caudate nucleus , anxiety , anterior cingulate cortex , psychology , neuroscience , cortex (anatomy) , oncology , nuclear medicine , psychiatry , central nervous system , cognition , insulin , economics , macroeconomics
Twenty German cancer patients (56.9±12.7 years old) without brain metastasis underwent neurological PET. The acquired brain data were compared to the data of ten age and sex‐matched controls (53.6±15.7). Scores of Zung's Self‐rating Depression Scale (SDS) obtained from 15 out of the 20 patients suggested they might be mildly depressed. Scores of Taylor's Manifest Anxiety Scale (MAS), used for additional psychological evaluation, were close to normal distribution. Hypometabolic areas in the German cancer patients were compared with those demonstrated in our previous study in Japanese cancer patients. Common findings in both studies were observed in the limbic structures, such as the anterior and posterior cingulate gyri, the basolateral frontal cortices, as well as in the basal ganglia (especially the caudate nucleus) and frontal cortex. These results are in accordance with many previous PET studies on major depression. The results show that the positron emission tomography and 18 F‐fluoro‐deoxyglucose ( 18 FDG‐PET) brain mapping results could be partially reproduced, and suggest that PET brain mapping of cancer patients has a potential clinical application to the field of psycho‐oncology and cancer patient care. Copyright © 2000 John Wiley & Sons, Ltd.