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Synthesis of chitosan–sugar hybrid and evaluation of its bioactivity
Author(s) -
Li Xuebing,
Morimoto Minoru,
Sashiwa Hitoshi,
Saimoto Hiroyuki,
Okamoto Yoshiharu,
Minami Saburo,
Shigemasa Yoshihiro
Publication year - 1999
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/(sici)1099-1581(199907)10:7<455::aid-pat895>3.0.co;2-e
Subject(s) - chitosan , materials science , sugar , polymer science , chemical engineering , biochemical engineering , organic chemistry , engineering , chemistry
Various chitosan–sugar hybrids were synthesized. The influence of the hybrids on the active oxygen generation of canine polymorphonuclear leukocyte (PMN) cells was investigated by measurement of the chemiluminescence (CL) response. The CL responses depended on the degree of substitution (DS) and water solubility of the hybrids. Water‐insoluble hybrids stimulated the PMN cells directly by phagocytosis and the water‐soluble ones would sensitize the PMN cells by a priming effect. Copyright © 1999 John Wiley & Sons, Ltd.