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Polymers in gene therapy: antisense delivery systems
Author(s) -
Israel Zvi H.,
Domb Abraham J.
Publication year - 1998
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/(sici)1099-1581(1998100)9:10/11<799::aid-pat807>3.0.co;2-n
Subject(s) - genetic enhancement , gene delivery , nanotechnology , computational biology , materials science , smart polymer , in vivo , gene , polymer , biology , microbiology and biotechnology , genetics , composite material
Antisense aligonucleotides can down‐regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. While effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non‐viral methods of antisense delivery and also describes some of the exciting potential clinical applications of this technology. © 1998 John Wiley & Sons, Ltd.