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Micelle‐like macromolecular systems for controlled release of daunomycin
Author(s) -
Gorshkova Marina Yu.,
Stotskaya Lena L.
Publication year - 1998
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/(sici)1099-1581(199806)9:6<362::aid-pat793>3.0.co;2-i
Subject(s) - micelle , macromolecule , conjugate , copolymer , drug delivery , ionic bonding , polymer , drug carrier , solubilization , maleic anhydride , ether , chemistry , polymer chemistry , organic chemistry , materials science , chemical engineering , aqueous solution , biochemistry , engineering , ion , mathematical analysis , mathematics
Soluble macromolecular conjugates for the delivery of the strongly hydrophobic anticancer drug daunomycin (DM) or rubomycin with its controlled release were prepared. The solution properties of these conjugates consisting of DM bonded to copolymer of maleic anhydride and divinyl ether (DIVEMA) and a few model compounds were investigated using adsorbance spectroscopy, as well as surface activity and solubilization of water‐insoluble dye measurements. The data of these studies indicated that in water solutions conjugates are associated, probably intramolecularly. This micellization in parallel with an H‐bonded ionic complex between DM and polymer carrier determines the DM release. It is concluded that the desirable drug release can be achieved through changing the structure of conjugates by means of varying the constituents hydrophobicity. © 1998 John Wiley & Sons, Ltd.