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Synthesis and relaxivity of polyamide paramagnetic metal complexes for magnetic resonance imaging
Author(s) -
Ouyang Ming,
Zhuo Renxi,
Fu Gongcheng
Publication year - 1996
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/(sici)1099-1581(199608)7:8<671::aid-pat557>3.0.co;2-9
Subject(s) - paramagnetism , gadolinium , polyamide , materials science , monomer , metal , diamine , manganese , nuclear magnetic resonance , ethylenediaminetetraacetic acid , polymer chemistry , macromolecule , chelation , polymer , chemistry , biochemistry , physics , quantum mechanics , metallurgy , composite material
A new class of paramagnetic macromolecular magnetic resonance imaging contrast agents has been developed. Eight new polyamide ligands were synthesized by copolymerization of ethylenediaminetetraacetic acid dianhydride or diethylenetriaminepentaacetic acid dianhydride and diamine monomers. Their gadolinium(III), manganese(II) and iron(III) complexes were also synthesized. All polyamide ligands and metal complexes were characterized by 1 H nuclear magnetic resonance, infrared spectra and elemental analyses. Relaxivity studies showed that the polyamide paramagnetic metal complexes had obviously higher relaxation effectiveness as compared to corresponding simple monomeric paramagnetic metal complexes.