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A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu
Author(s) -
Ghorai Mousumi,
Mandal Subhash C.,
Pal M.,
Pal S. P.,
Saha B. P.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(200005)14:3<200::aid-ptr548>3.0.co;2-t
Subject(s) - allicin , gram , cholesterol , traditional medicine , west bengal , medicine , germination , phytotherapy , chemistry , food science , biology , botany , bacteria , socioeconomics , genetics , alternative medicine , pathology , sociology
The daily use of allicin and whole germinated bengal gram seeds for 8 weeks led to a significant decrease in serum cholesterol levels in normal volunteers with no side effects. The standard reference, guggulipid therapy, significantly ( p < 0.001) reduced the mean serum cholesterol level to 142.88 ± 24.14 mg/100 mL from an initial status of 211.91 ± 6.23 mg/100mL (32.36% ± 12.48% fall). Allicin treatment significantly reduced the mean serum cholesterol level to 129.99 ± 2.79 mg/100 mL from a pre‐treatment value of 148.10 ± 8.81 mg/100mL, a fall of 13.36% ± 4.64%. The serum cholesterol value was reduced to 135.62± 22.85 mg/100 mL from a pre‐treatment value of 157.29 ± 4.94 mg/100mL (17.15% ± 9.94% fall) due to daily use of whole germinated bengal gram seeds. Hence the hypocholesterolaemic effects of allicin and whole germinated bengal gram seeds are comparable to the established standard reference, guggulipid. These two materials are herbal in origin and it is supposed to have a lesser risk‐benefit ratio compared with other available synthetic drugs. The inclusion of these herbal products in the normal diet may be an alternative effective measure for hypercholesterolaemia. Copyright © 2000 John Wiley & Sons, Ltd.