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Myocardial protection against ischaemia‐ reperfusion injury by a Polygonum multiflorum extract supplemented ‘Dang‐Gui decoction for enriching blood’, a compound formulation, ex vivo
Author(s) -
Yim T. K.,
Wu W. K.,
Pak W. F.,
Mak D. H. F.,
Liang S. M.,
Ko K. M.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(200005)14:3<195::aid-ptr629>3.0.co;2-4
Subject(s) - decoction , polygonum , ex vivo , antioxidant , traditional medicine , reperfusion injury , pharmacology , oxidative stress , astragalus , in vivo , angelica sinensis , medicine , ischemia , pharmacognosy , chemistry , biological activity , traditional chinese medicine , biochemistry , in vitro , biology , pathology , alternative medicine , microbiology and biotechnology
‘Dang‐Gui Decoction for Enriching the Blood’ (BE), a traditional Chinese formulation comprising Angelica sinensis and Astragalus membranaceus , is used for stimulating red blood cell production as well as enhancing cardiovascular function. In the present study, we have demonstrated the myocardial protection afforded by BE pretreatment against ischaemia‐reperfusion (IR) injury in isolated‐perfused rat hearts. A more complete and potent myocardial protection against IR injury was also shown by a Polygonum multiflorum extract supplemented BE preparation (BEA). The results suggest that the more potent cardioprotective action of BEA may be related to its ability to sustain the myocardial glutathione antioxidant status under conditions of IR‐induced oxidative stress, which may possibly in turn result from the synergistic interaction between the BE and Polygonum extract. Copyright © 2000 John Wiley & Sons, Ltd.