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Antiviral effect of flavonoids on the Dengue virus
Author(s) -
Sánchez I.,
GómezGaribay F.,
Taboada J.,
Ruiz B. H.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(200003)14:2<89::aid-ptr569>3.0.co;2-c
Subject(s) - dengue fever , dengue virus , virus , virology , traditional medicine , flaviviridae , in vitro , biology , pharmacognosy , chemistry , biological activity , viral disease , medicine , biochemistry
Abstract In the present study we analysed the possible antiviral effect on dengue viruses of different flavonoids extracted and identified at the Chemistry Institute, UNAM, from the Mexican plants Tephrosia madrensis, Tephrosia viridiflora and Tephrosia crassifolia . The flavonoids glabranine and 7‐O‐methyl‐glabranine presented 70% inhibition on the dengue virus at a concentration of 25 µ M , while methyl‐hildgardtol A, hildgardtol A and elongatine had no effect on viral growth. Our results show that glabranine and 7‐O‐methyl‐glabranine isolated from Tephrosia s.p . exert a dose‐dependent inhibitory effect in vitro on the dengue virus. Copyright © 2000 John Wiley & Sons, Ltd.