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Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats
Author(s) -
Pari L.,
Umamaheswari J.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(200003)14:2<136::aid-ptr607>3.0.co;2-k
Subject(s) - tbars , glibenclamide , glutathione peroxidase , antioxidant , catalase , alloxan , superoxide dismutase , thiobarbituric acid , lipid peroxidation , chemistry , glutathione , traditional medicine , diabetes mellitus , food science , biochemistry , biology , medicine , endocrinology , enzyme
Musa sapientum commonly known as ‘banana’ is widely used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 0.15, 0.20 and 0.25 g/kg body weight of the chloroform extract of the flowers for 30 days resulted in a significant reduction in blood glucose and glycosylated haemoglobin and an increase in total haemoglobin. The extract prevented a decrease in body weight, and also resulted in a decrease in free radical formation in the tissues. Thus the study shows that banana flower extract (BFEt) has an antihyperglycaemic action. The decrease in thiobarbituric acid reactive substances (TBARS) and the increase in reduced glutathione (GSH), glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD) and catalase (CAT) clearly shows the antioxidant property of BFEt. The effect of BFEt was more prominently seen in the case of animals given 0.25 g/kg body weight. BFEt was more effective than glibenclamide. Copyright © 2000 John Wiley & Sons, Ltd.