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Effect of Ocimum sanctum roots extract on swimming performance in mice
Author(s) -
Maity Tapan K.,
Mandal Subhash C.,
Saha B. P.,
Pal M.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(200003)14:2<120::aid-ptr557>3.0.co;2-0
Subject(s) - ocimum , traditional medicine , desipramine , stimulant , pharmacognosy , antidepressant , biology , medicine , pharmacology , biological activity , in vitro , endocrinology , biochemistry , hippocampus
The effect of a methanol extract, obtained from the roots of Ocimum sanctum , on mouse swimming performance were studied using three different doses. On the basis of our findings, a high dose (400 mg/kg, i.p.) of the extracts of Ocimum sanctum increased the swimming time suggesting a central nervous system stimulant and/or antistress activity. The effect produced by the extract was comparable to that of desipramine, an antidepressant drug. Copyright © 2000 John Wiley & Sons, Ltd.