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Inhibition of nitric oxide release by an aqueous extract of Tinospora tuberculata
Author(s) -
Yokozawa Takako,
Wang Tian Shan,
Chen Cui Ping,
Hattori Masao
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(200002)14:1<51::aid-ptr545>3.0.co;2-k
Subject(s) - nitric oxide , pharmacognosy , traditional medicine , chemistry , aqueous solution , aqueous extract , biological activity , pharmacology , biology , medicine , in vitro , biochemistry , organic chemistry
An aqueous extract of Tinospora tuberculata stems was found to scavenge nitric oxide (NO) in vitro in both cell and cell‐free systems. When the aqueous extract was added to lipopolysaccharide‐stimulated murine macrophages, it inhibited NO release dose‐dependently, and similar activity was found in a cell‐free system using sodium nitroprusside as a NO donor. These findings may help to explain, in part, certain pharmacological activities of Tinospora tuberculata . Copyright © 2000 John Wiley & Sons, Ltd.