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Antioestrogenic effect of trans ‐dehydrocrotonin, a nor‐clerodane diterpene from Croton cajucara Benth. in rats
Author(s) -
Costa A. M. Luna,
Silva J. C. R.,
Campos A. R.,
Rao V. S. N.,
Maciel M. A. M.,
Pinto A. C.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199912)13:8<689::aid-ptr532>3.0.co;2-l
Subject(s) - diterpene , croton , traditional medicine , bioassay , biology , pharmacology , chemistry , stereochemistry , medicine , genetics
This study examined trans ‐dehydrocrotonin ( t ‐DCTN), a nor‐clerodane diterpene isolated from the Brazilian medicinal plant Croton cajucara Benth., for a possible antioestrogenic activity using immature rats as a model system for bioassay of oestrogen, and for an antiimplantation effect in regularly cycling rats of proven fertility. In the antioestrogen test, t ‐DCTN (25 and 50 mg/kg) effectively prevented oestrogen‐induced increases of uterine wet weights. In addition, the vaginal openings provoked by oestrogen were completely prevented by t‐DCTN. However, blastocyst‐implantation was only insignificantly affected in t ‐DCTN pretreated animals. These results suggest that t ‐DCTN may be an antioestrogen and warrants further studies with regard to its mechanism of action. Copyright © 1999 John Wiley & Sons, Ltd.