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Vascular effects of aqueous crude extracts of Artemisia verlotorum Lamotte (Compositae): in vivo and in vitro pharmacological studies in rats
Author(s) -
Calderone Vincenzo,
Martinotti Enrica,
Baragatti Barbara,
Cristina Breschi Maria,
Morelli Ivano
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199912)13:8<645::aid-ptr496>3.0.co;2-m
Subject(s) - nitric oxide , cyclic guanosine monophosphate , pharmacology , vasodilation , in vivo , artemisia , pharmacognosy , traditional medicine , in vitro , chemistry , atropine , guanosine , medicine , biology , biochemistry , biological activity , anesthesia , endocrinology , microbiology and biotechnology
Artemisia verlotorum Lamotte (Compositae), growing in almost all the northern hemisphere, is used in folk medicine of some countries of Tuscany, Italy, as a remedy for hypertension. The pharmacological evaluation of the responses evoked by an aqueous dried extract of Artemisia verlotorum on the blood pressure of anaesthetized rats and on in vitro rat isolated aortae showed a marked, but transient, hypotensive activity. This effect was mediated by a strong vasodilator action, closely linked to the release of endothelial nitric oxide and to the nitric oxide‐guanosine 3′–5′‐cyclic monophosphate (cGMP) pathway, caused by a muscarinic receptor agonism. Copyright © 1999 John Wiley & Sons, Ltd.