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Therapeutic effect of Oren‐gedoku‐to extract on stress‐induced acute gastric mucosal lesions in rats
Author(s) -
Ohta Yoshiji,
Kobayashi Takashi,
Nishida Keiji,
Nagata Minoru,
Ishiguro Isao
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199911)13:7<588::aid-ptr505>3.0.co;2-p
Subject(s) - medicine , therapeutic effect , lipid peroxidation , lipid peroxide , lesion , gastric mucosa , xanthine oxidase , phytotherapy , stomach , oxidative stress , gastritis , traditional chinese medicine , pharmacology , gastroenterology , infiltration (hvac) , oral administration , pathology , chemistry , biochemistry , enzyme , alternative medicine , physics , thermodynamics
Oral administration of Oren‐gedoku‐to extract (TJ‐15), a traditional Chinese herbal medicine for the therapy of gastric ulcers and gastritis, dose‐dependently prevented the progression of acute gastric mucosal lesions in rats with water immersion restraint (WIR) stress. The preventive effect of TJ‐15 on the lesion progression was stronger than that of Saiko‐keishi‐to extract (TJ‐10) or Shigyaku‐san extract (TJ‐35), each of which is a traditional Chinese herbal medicine for the therapy of gastric ulcers and gastritis, when compared on the basis of a single dosage of each medicine for adults. This TJ‐15 administration attenuated increases in gastric mucosal lipid peroxide concentration and xanthine oxidase and myeloperoxidase activities with the gastric mucosal lesion progression and recovered the decreased gastric mucosal non‐protein SH concentration found at a progressed stage of the gastric mucosal lesions. These results indicate that TJ‐15 exerts a therapeutic effect on WIR stress‐induced acute gastric lesions in rats more strongly than TJ‐10 or TJ‐35, and suggest that the therapeutic effect of TJ‐15 could be due to its preventive actions on lipid peroxidation and sulphydryl oxidation via oxygen free radicals generated by the xanthine–XO system and infiltrated neutrophils in the gastric mucosa and on neutrophil infiltration into the tissue. Copyright © 1999 John Wiley & Sons, Ltd.